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Rothamsted Research

where knowledge grows

Scientific Technician

Salary Details:
£24,225 to £26,573
AL5 2JQ, Herts, UK
Work Area:
Science Capabilities
04 Oct 2021
Overview Of Role
Applications are invited for a Scientific Technician Band C with an interest in chromatin biology to work in the laboratory of Dr Christophe Lambing in the Plant Sciences Department at Rothamsted Research.
Our main research aims to understand how meiotic recombination is regulated during reproductive development. During meiosis, a specific protein complex forms around 2,000 DNA double-strand breaks throughout the entire wheat genome. This special form of DNA break can be deleterious for the cell if improperly repaired. However, meiotic DNA breaks are processed by a DNA-repair mechanism called inter-homologue recombination. This repair pathway is unique to germ cells and facilitates the exchange of genetic information between the two pairs of chromosomes. These events contribute to the formation of new allelic combinations and the formation of a genetically diverse offspring population. Thus, meiotic recombination has been a driving force to create novel genetic diversity during evolution. The aim of our group is to understand how this DNA repair mechanism is controlled in order to design innovative strategies to target recombination in specific parts of the genomes with the goal to accelerate wheat breeding.
The primary function of the position is to assist with research projects in the laboratory. The tasks involve bacterial and plant transformation, CRISPR-based mutagenesis, RNAi/VIGS-induced down-regulation of gene expression, greenhouse research assistance, extraction of DNA and RNA, PCRs, cloning, isolation of nuclei and preparation of plant chromosomes for visualisation under a microscope. This position is an excellent opportunity to learn cutting-edge technologies.
The ideal candidate will have practical laboratory experience, preferably in molecular biology, and ideally be at university undergraduate level or above. Training of new experimental procedures will be provided. It is expected that the successful applicant proactively supports the work of the whole team, demonstrates excellent ability to understand concepts related to laboratory work, and performs experiments with high level of accuracy.
This is a full-time fixed term for 2 years in the first instance, with a salary in the range of £24,225 to £26,573 per annum.
For informal enquiries about this position please contact Dr Christophe Lambing (christophe.lambing@rothamsted.ac.uk).
Closing date:  4th October 2021
Interviews:    week commencing 11th October 2021
About The Company
Established in 1843, Rothamsted Research is one of the UK's leading Research Institutes delivering world class agricultural science.  Our commitment to learning and development, equality and diversity as well as creating a positive work life balance,  enable a welcoming environment for all prospective employees.  We have an attractive benefits package including 25 days annual leave, a generous pension scheme and an attractive campus offering cultural and recreational activities.  Rothamsted Research values its commitment to equality and diversity in its workforce and we particularly encourage applications from women, disabled and Black, Asian and Minority Ethnic (BAME) candidates, as these groups are currently under-represented within the organisation.